ID   HRCA_ACAM1              Reviewed;         367 AA.
AC   B0C2W4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=AM1_1142;
OS   Acaryochloris marina (strain MBIC 11017).
OC   Bacteria; Cyanobacteria; Synechococcales; Acaryochloridaceae;
OC   Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBIC 11017;
RX   PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA   Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA   Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA   Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA   Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA   Blankenship R.E., Touchman J.W.;
RT   "Niche adaptation and genome expansion in the chlorophyll d-producing
RT   cyanobacterium Acaryochloris marina.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000828; ABW26180.1; -; Genomic_DNA.
DR   RefSeq; WP_012161730.1; NC_009925.1.
DR   AlphaFoldDB; B0C2W4; -.
DR   SMR; B0C2W4; -.
DR   STRING; 329726.AM1_1142; -.
DR   EnsemblBacteria; ABW26180; ABW26180; AM1_1142.
DR   KEGG; amr:AM1_1142; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000268; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..367
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075277"
SQ   SEQUENCE   367 AA;  40913 MW;  CFE29F5805C614A8 CRC64;
     MDLSLTNRQQ QVLRATVDHY IATAEPVGSK ALAREYALSI SPATIRNVMG RLEEEGLLFQ
     PHTSAGRVPS DFGYRHYVDE LVMPSTTLMS QIKQALDQKL RTDSWIFEVL LRDAAQILAT
     LSGCVALITL PQAATSTIRH LHLVQVEPHR VMLILVTDAY ETQSVMMELP HSAWDEVDPD
     RIEQELQILS NFLNHHFVGS SLQDLVALDP CELDREFQKY TDFLKILLTD LTQQCKSLSP
     KNILVGGLAE VLRQPEFSEL QQAQTLIHLL EDGQDLLRPL FNELMADEIK QGADVVPRST
     KVNVRIGSEN SLESIQAYSL VSSTYQKGEL PMGSVGVLGP TRMAYEKVIA LVTVTADYLS
     TCLTQVA