ID   HRCA_ACHLI              Reviewed;         342 AA.
AC   A9NFN6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=ACL_0548;
OS   Acholeplasma laidlawii (strain PG-8A).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC   Acholeplasma.
OX   NCBI_TaxID=441768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG-8A;
RX   PubMed=21784942; DOI=10.1128/jb.05059-11;
RA   Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A.,
RA   Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D.,
RA   Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A.,
RA   Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I., Alexeev D.G.,
RA   Ladygina V.G., Govorun V.M.;
RT   "Complete genome and proteome of Acholeplasma laidlawii.";
RL   J. Bacteriol. 193:4943-4953(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000896; ABX81166.1; -; Genomic_DNA.
DR   RefSeq; WP_012242497.1; NC_010163.1.
DR   AlphaFoldDB; A9NFN6; -.
DR   SMR; A9NFN6; -.
DR   STRING; 441768.ACL_0548; -.
DR   EnsemblBacteria; ABX81166; ABX81166; ACL_0548.
DR   GeneID; 66293545; -.
DR   KEGG; acl:ACL_0548; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008558; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075278"
SQ   SEQUENCE   342 AA;  38994 MW;  1CD391D2AC2CB320 CRC64;
     MISSRQKLIL KAIIDMYSEK GEPVGSKALM ALPYLNYSSA TLRYDMAVLE ELGFLEKMHT
     SSGRVPSERG YRYYIEHLVT RDNDVTEVFP LIDEVFSKKA LGREHTIKEA LKLLTDLTSY
     TAVAVGPDIL QSHIKRIEMV PLGLKDAVML IVTDTGHVQH QQIHISDDMR MDDIKEVIHT
     LDDLLKNRTL EDALKVLKEE YAISELNQFM SYQSQIIDSF IEAFSKFASD SFYLSGMTNA
     FEQPEFNDVS HMKRFIDMMD RREIVKLIGT AEGISVRFGS DMEIKPLNQM TIISIPYQID
     SKQKGTIALV GPSRMSYQKV IPLLEYIAAN LAKLYKDNNK ET