ID   HRCA_ACIET              Reviewed;         334 AA.
AC   B9MEI9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Dtpsy_0847;
OS   Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Diaphorobacter.
OX   NCBI_TaxID=535289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TPSY;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Coates J.D.;
RT   "Complete sequence of Diaphorobacter sp. TPSY.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001392; ACM32325.1; -; Genomic_DNA.
DR   RefSeq; WP_012655817.1; NC_011992.1.
DR   AlphaFoldDB; B9MEI9; -.
DR   SMR; B9MEI9; -.
DR   STRING; 535289.Dtpsy_0847; -.
DR   EnsemblBacteria; ACM32325; ACM32325; Dtpsy_0847.
DR   KEGG; dia:Dtpsy_0847; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000450; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118302"
SQ   SEQUENCE   334 AA;  36874 MW;  39A5D104207C53F3 CRC64;
     MLDDRSKLLL KALVERYIAE GQPVGSRTLS RASGLELSPA TIRNVMADLE DLGLIASPHT
     SAGRVPTAKG YRLFVDTMLT VQQEQLPTVQ LMPEQPQKVI ANAAHLLSSL SQFVGVVMAP
     RRASVFRHIE FLRLSEKRFL VIIVSPDGDV QNRVIFTEAD YSQSQLVEAA NFLNANYAGL
     TMEQVRERLK LEVDKLRGEI AALMQAAVSV DSEAMSGSQD EVVFSGERNL LSVSDFSSDM
     SHLRRAFDLF EQKTQILRLL DISSRAEGVR IFIGGESQVV PFEELSVVSA PYEVDGQVVG
     TLGVIGPTRM PYDRMIQIVD ITSKLVSNAL SHRK