HRCA_ACISJ
ID HRCA_ACISJ Reviewed; 334 AA.
AC A1W4H2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Ajs_0905;
OS Acidovorax sp. (strain JS42).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax; unclassified Acidovorax.
OX NCBI_TaxID=232721;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS42;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T.,
RA Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
RT "Complete sequence of chromosome 1 of Acidovorax sp. JS42.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP000539; ABM41147.1; -; Genomic_DNA.
DR RefSeq; WP_011804349.1; NC_008782.1.
DR AlphaFoldDB; A1W4H2; -.
DR SMR; A1W4H2; -.
DR STRING; 232721.Ajs_0905; -.
DR EnsemblBacteria; ABM41147; ABM41147; Ajs_0905.
DR KEGG; ajs:Ajs_0905; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_4; -.
DR OMA; DYPGTMG; -.
DR Proteomes; UP000000645; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..334
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000118282"
SQ SEQUENCE 334 AA; 36833 MW; F4C2E714DC368E47 CRC64;
MLDDRSKLLL KALVERYIAE GQPVGSRTLS RASGLELSPA TIRNVMADLE DLGLIASPHT
SAGRVPTAKG YRLFVDTMLT VQQEQLPTVQ LMPEQPQKVI ANAAHLLSSL SQFVGVVMAP
RRASVFRHIE FLRLSEKRFL VIIVSPDGDV QNRVIFTEVD YSQSQLVEAA NFLNANYAGL
TMEQVRERLK LEVDKLRGEI AALMQAAVSV GSEAMSGSQD EVVFSGERNL LSVSDFSSNM
SHLRRAFDLF EQKTQILRLL DISSRAEGVR IFIGGESQVV PFEELSVVSA PYEVDGQVVG
TLGVIGPTRM SYDRMIQIVD ITSKLVSNAL SHRK