ID   HRCA_AFIC5              Reviewed;         363 AA.
AC   B6JCI0; F8BRE5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=OCAR_4414, OCA5_c01170;
OS   Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
OS   (Oligotropha carboxidovorans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Afipia.
OX   NCBI_TaxID=504832;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49405 / DSM 1227 / KCTC 32145 / OM5;
RX   PubMed=18539730; DOI=10.1128/jb.00614-08;
RA   Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.;
RT   "Genome sequence of the chemolithoautotrophic bacterium Oligotropha
RT   carboxidovorans OM5T.";
RL   J. Bacteriol. 190:5531-5532(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49405 / DSM 1227 / KCTC 32145 / OM5;
RX   PubMed=21742883; DOI=10.1128/jb.05619-11;
RA   Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G.,
RA   Meyer O.;
RT   "Complete genome sequences of the chemolithoautotrophic Oligotropha
RT   carboxidovorans strains OM4 and OM5.";
RL   J. Bacteriol. 193:5043-5043(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001196; ACI91560.1; -; Genomic_DNA.
DR   EMBL; CP002826; AEI04849.1; -; Genomic_DNA.
DR   RefSeq; WP_012561591.1; NC_015684.1.
DR   AlphaFoldDB; B6JCI0; -.
DR   SMR; B6JCI0; -.
DR   STRING; 504832.OCAR_4414; -.
DR   EnsemblBacteria; AEI04849; AEI04849; OCA5_c01170.
DR   KEGG; oca:OCAR_4414; -.
DR   KEGG; ocg:OCA5_c01170; -.
DR   PATRIC; fig|504832.7.peg.124; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000007730; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092824"
SQ   SEQUENCE   363 AA;  39430 MW;  66B51FDECF9FA056 CRC64;
     MSHHDPKEAL ITPGAALSQL NERSRDIFRQ IVENYLATGE PVGSRNISRM ISVPLSPASV
     RNVMADLEQL GLIYAPHTSA GRLPTELGLR FFVDALMQVG DLTEDERQSI QAQLAAIGKQ
     QSIEATLSDA MMRLSGLTRA AAVVLTGKSN PRLKHIEFVR LEPEQALVVL VSEDGQIENR
     VLALPPGVPS SALIEASNFL NSRIRGRTLS EVRGELEAAL AQRRSELDQL TQKIIAAGVA
     SWSGGSSDER RLIVRGHANL LEDLHAMEDL ERVRLLFDDL ETKKGVADLL GLAEQGEGVR
     IFIGSENKLF SLSGSSTITA PYRDSSGRIV GVLGVIGPTR LNYARVIPMV DYAARIVSQM
     LGK