ID   HRCA_ANAD2              Reviewed;         353 AA.
AC   B8JCT2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=A2cp1_4485;
OS   Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=455488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-1 / ATCC BAA-258;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Beliaev A.S., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001359; ACL67802.1; -; Genomic_DNA.
DR   RefSeq; WP_012528413.1; NC_011891.1.
DR   AlphaFoldDB; B8JCT2; -.
DR   SMR; B8JCT2; -.
DR   EnsemblBacteria; ACL67802; ACL67802; A2cp1_4485.
DR   KEGG; acp:A2cp1_4485; -.
DR   HOGENOM; CLU_050019_0_0_7; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000007089; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..353
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118284"
SQ   SEQUENCE   353 AA;  38646 MW;  2C3CC3BE5908F9A8 CRC64;
     MASADELDRR EREILRALVQ DYIHTGEPVA SQPLLSRHEL EWSPATVRSV MADLEALGFL
     EKPHASSGRI PTERGYRLFV DTMLKVRPPS VADRDRIERL AQAAPDVSSL IEGTADLLHS
     LSHHAGVVTT PRPQADPVRQ LEFVRLRENR VLVVFVSEAG IVTNKLVQLE FAMEPAELER
     AAAYLNEKLH ARADAAELAA LRAAILTDMR ADQSALHDLL QKALVLAEQS FAGTGVEKVV
     MEGESSFLDA PEFSDVQKAR ALLRGFAEKD RILRVLDRVL TAQEVQIFIG AESEFATVPD
     VSVVAAPYGR GDRVLGTLAV VGPTRMNYAR VIPLVDLTAR QISRALAALS EGG