ID   HRCA_ANADE              Reviewed;         355 AA.
AC   Q2IHN8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Adeh_4330;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000251; ABC84093.1; -; Genomic_DNA.
DR   RefSeq; WP_011423375.1; NC_007760.1.
DR   AlphaFoldDB; Q2IHN8; -.
DR   SMR; Q2IHN8; -.
DR   STRING; 290397.Adeh_4330; -.
DR   PRIDE; Q2IHN8; -.
DR   EnsemblBacteria; ABC84093; ABC84093; Adeh_4330.
DR   KEGG; ade:Adeh_4330; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_7; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..355
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010372"
SQ   SEQUENCE   355 AA;  38826 MW;  4C999854E5BB6D4D CRC64;
     MATADELDRR EREILRALVQ DYIHTGEPVA SQPLLSRHEL EWSPATVRSV MADLEALGFL
     EKPHASSGRI PTERGYRLYV DTMLKVRPPS PADRDRIERL AQAAPDVSSL IEGTADLLHS
     LSHHAGVVTT PRPQADPVRQ LEFVRLRENR VLVVFVSAAG IVTNKLVQLE FTMEPAELER
     AAAYLNEKLH ARAEAAEPEL AALRAAILGD MRADQSALHD LLQKALVLAE QSFAAAGVEK
     VVMEGESSFL DAPEFSDVQK ARALLRGFAE KDRILRVLDR VLTAQEVQIF IGAESEFATV
     PDVSVVAAPY GRGDRVLGTL AVVGPTRMNY ARVIPLVDLT ARQISRALAA LSEGG