ID   HRCA_ANASL              Reviewed;         357 AA.
AC   Q5EF74;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081, ECO:0000312|EMBL:AAX07322.1};
OS   Anabaena sp. (strain L31).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena;
OC   unclassified Anabaena.
OX   NCBI_TaxID=29412;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAX07322.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Rajaram H., Schumann W., Apte S.K.;
RT   "Regulation of heat shock response in the nitrogen-fixing cyanobacterium,
RT   Anabaena sp. strain L-31.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAX07322.1}
RP   PROTEIN SEQUENCE OF 9-18; 31-46 AND 185-198.
RA   Rajaram H., Apte S.K.;
RT   "Negative regulation of Hsp60 proteins of Anabaena by hrcA at CIRCE.";
RL   Submitted (DEC-2008) to UniProtKB.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000250|UniProtKB:Q45550, ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AY897588; AAX07322.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5EF74; -.
DR   SMR; Q5EF74; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000366198"
SQ   SEQUENCE   357 AA;  39852 MW;  313B10D46A455A6D CRC64;
     MQVQLTNRQQ HILWATVRHY IATAEPVGSK ALIEEYDLGV SSATIRNVMG VLEKSGLLYQ
     PHTSAGRVPS DSGYRIYVDK LITPSEVLAK EVESALQQRL QWEDWSLEIL LQGAAQILAS
     LSGCISLITM PQTNTATVRH LQLMQIEAGR IMLILVTDNY ETHSKLMDLP PGRSEKPDPE
     VIDRELQIVS NFLNSHLRGR SLLEITTLDW SQLDREFQLY GEFLKTSVAG LANRTAAPAA
     TQIMVRGVAE VLRQPEFSQL QQVQTIIQLL EEEQEQLWRL IFEEPELEDT NKSKVTVRIG
     AENPLEPIRT CSLISSTYRR GAVPLGSVGS SRPSRLDYEN AIAVVAAAAD YLSEAFS