ID   HRCA_ANOFW              Reviewed;         344 AA.
AC   B7GKC6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Aflv_0833;
OS   Anoxybacillus flavithermus (strain DSM 21510 / WK1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX   NCBI_TaxID=491915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21510 / WK1;
RX   PubMed=19014707; DOI=10.1186/gb-2008-9-11-r161;
RA   Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A.,
RA   Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V.,
RA   Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.;
RT   "Encapsulated in silica: genome, proteome and physiology of the
RT   thermophilic bacterium Anoxybacillus flavithermus WK1.";
RL   Genome Biol. 9:R161.1-R161.16(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000922; ACJ33211.1; -; Genomic_DNA.
DR   RefSeq; WP_012574501.1; NC_011567.1.
DR   AlphaFoldDB; B7GKC6; -.
DR   SMR; B7GKC6; -.
DR   STRING; 491915.Aflv_0833; -.
DR   EnsemblBacteria; ACJ33211; ACJ33211; Aflv_0833.
DR   KEGG; afl:Aflv_0833; -.
DR   PATRIC; fig|491915.6.peg.853; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000742; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000117105"
SQ   SEQUENCE   344 AA;  38964 MW;  FAC668D092076300 CRC64;
     MLSDRQLLIL KIIVDDFIRS GQPVGSRTLS KKEQITFSSA TIRNEMADLE ELGFIEKTHI
     SSGRVPSQKG YRYYVDHLLP PVRLTQKDVQ TIQSIFHEQI YELEKLIQKS AQILSDLTNY
     TTVVLGPSVK EHKLKTIQII PLNAETAVAI IVTDTGYVEK HVVTLPPSIP PSDVEKMVNI
     LNERLTGVPL EDLTDKIQTE VAHVLREHIQ SYDHMLRMIS SSLDLNAPAQ MFLSGKMNML
     RQPEFSDIDK LRGLFNIIEQ EKEFYRLLRK HNQQGIQVKI GTENDVEGME NCSLITATYS
     VGGEKLGTIA VLGPTRMEYS RVISLLNLVA TDLSKALTMW YQKD