ID   HRCA_ARTS2              Reviewed;         337 AA.
AC   A0JX46;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Arth_2236;
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24;
RX   PubMed=24501649; DOI=10.4056/sigs.4438185;
RA   Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA   Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT   "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL   Stand. Genomic Sci. 9:106-116(2013).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000454; ABK03616.1; -; Genomic_DNA.
DR   RefSeq; WP_011692080.1; NC_008541.1.
DR   AlphaFoldDB; A0JX46; -.
DR   SMR; A0JX46; -.
DR   STRING; 290399.Arth_2236; -.
DR   EnsemblBacteria; ABK03616; ABK03616; Arth_2236.
DR   KEGG; art:Arth_2236; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..337
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010374"
SQ   SEQUENCE   337 AA;  36282 MW;  2747F37C9152D96E CRC64;
     MSEPRKLEVL RAIVEDYVHS REPVGSKALV ERHHLGVSSA TIRNDMAALE DEGLITAPHT
     SAGRIPTDKG YRLFVDQISA VKPLSQAERR AIQTLLEGSE DLDDVLERTV RLLSQLTNQV
     AVVQYPHLSR AMVRHIEFVL LAPRQVLIVL IADTGKVEQR VIDVGQELGD DALAGLRARF
     LKSLAGTPLS LLPQALPAVV AGCEPSRRHA AQALARGLDA LASSSREERM VMAGTANLAR
     SNVDFPLSIG PVLEALEEQV VMLRLLSDMA QDPRGVTVSI GRENPYDGLA EASVVATGYG
     PGSSAKVGVL GPTRMDYPTT MAAVRAVARY LSRILGP