ID   HRCA_BACC0              Reviewed;         338 AA.
AC   B7JN41;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=BCAH820_4338;
OS   Bacillus cereus (strain AH820).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405535;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AH820;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus AH820.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001283; ACK87627.1; -; Genomic_DNA.
DR   RefSeq; WP_000954957.1; NC_011773.1.
DR   AlphaFoldDB; B7JN41; -.
DR   SMR; B7JN41; -.
DR   EnsemblBacteria; ACK87627; ACK87627; BCAH820_4338.
DR   KEGG; bcu:BCAH820_4338; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001363; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000117106"
SQ   SEQUENCE   338 AA;  37932 MW;  758743E3648D50F4 CRC64;
     MLTERQLLIL QTIIDDFIGS AQPVGSRTLA KKDEITYSSA TIRNEMADLE ELGFIEKTHS
     SSGRVPSEKG YRFYVDHLLA PQNLPNDEIV QIKDLFAERI FEAEKIAQQS AQILSELTNY
     TAIVLGPKLS TNKLKNVQIV PLDRQTAVAI IVTDTGHVQS KTITVPESVD LSDLEKMVNI
     LNEKLSGVPM SELHNKIFKE IVTVLRGYVH NYDSAIKMLD GTFQVPLSEK IYFGGKANML
     SQPEFHDIHK VRSLLTMIDN EAEFYDILRH KQVGIQVKIG RENSATAMED CSLISATYSI
     GEEQLGTIAI LGPTRMQYSR VISLLQLFTR QFTDGLKK