ID   HRCA_BACC1              Reviewed;         338 AA.
AC   Q730L9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BCE_4397;
OS   Bacillus cereus (strain ATCC 10987 / NRS 248).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10987 / NRS 248;
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE017194; AAS43298.1; -; Genomic_DNA.
DR   RefSeq; WP_000954951.1; NC_003909.8.
DR   AlphaFoldDB; Q730L9; -.
DR   SMR; Q730L9; -.
DR   EnsemblBacteria; AAS43298; AAS43298; BCE_4397.
DR   GeneID; 59155112; -.
DR   KEGG; bca:BCE_4397; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002527; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182441"
SQ   SEQUENCE   338 AA;  37857 MW;  B603F5DDABD2924F CRC64;
     MLTERQLLIL QTIIDDFIGS AQPVGSRTLA KKDEITFSSA TIRNEMADLE ELGFIEKTHS
     SSGRVPSEKG YRFYVDHLLA PQNLPNDEIV QIKDLFAERI FEAEKIAQQS AQILSELTNY
     TAIVLGPKLS TNKLKNVQIV PLDRQTAVAI IVTDTGHVQS KTITVPESVD LSDLEKMVNI
     LNEKLSGVPM SELHNKIFKE IVTVLRGYVH NYDSAIKILD GTFQVPLSEK IYFGGKANML
     SQPEFHDIQK VRSLLTMIDN EAEFYDILRH KQVGIQVKIG RENSSTAMED CSLISATYSI
     GEEQVGTIAI LGPTRMQYSR VISLLQLFTR QITDGLKK