ID   HRCA_BARHE              Reviewed;         356 AA.
AC   Q6G564;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BH00550;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX897699; CAF26871.1; -; Genomic_DNA.
DR   RefSeq; WP_011180018.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G564; -.
DR   SMR; Q6G564; -.
DR   STRING; 283166.BH00550; -.
DR   PaxDb; Q6G564; -.
DR   PRIDE; Q6G564; -.
DR   DNASU; 2865129; -.
DR   EnsemblBacteria; CAF26871; CAF26871; BH00550.
DR   GeneID; 64156363; -.
DR   KEGG; bhe:BH00550; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..356
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182451"
SQ   SEQUENCE   356 AA;  39440 MW;  BCBBB4BF995FE495 CRC64;
     MKHKLIDDEL KYLDERSRDI FRHIVEAYLN DGGPVGSRNL SRLLRQTLSP ATIRNVMSDL
     EHLGLIYAPH VSAGRMPTQS GLRFFVDAFM EAGDLPNEER ENIEAQVKEA GHAQSVEHFL
     VQASQVLSDL SRGAGLVLAT KHEGTLKHIE FVRLDGEHAL AVLVTQQGGV ENRIVHLPEG
     VTHAQLTEAT NFLNAHIQGL TLSEAKEEIA RLCSETRAAL DHLSHHLVET GLALWGGEGA
     DHKIRLIVRG RSNLLEDVKA EEDLKRLRHL FDDLETRESM AQLLDLTDEG SGVRIFIGSE
     NKLFSLSGSS LVVAPYRDSQ QKVIGALGVI GPTRLNYARI VPMVDYTAQL VSQLLR