ID   HRCA_BIFA0              Reviewed;         366 AA.
AC   B8DUG2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BLA_1356;
OS   Bifidobacterium animalis subsp. lactis (strain AD011).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=442563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AD011;
RX   PubMed=19011029; DOI=10.1128/jb.01515-08;
RA   Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H.,
RA   Kim D.-W., Ji G.E., Park H.-S., Oh T.K.;
RT   "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp.
RT   lactis AD011.";
RL   J. Bacteriol. 191:678-679(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001213; ACL29641.1; -; Genomic_DNA.
DR   RefSeq; WP_004217935.1; NC_011835.1.
DR   AlphaFoldDB; B8DUG2; -.
DR   SMR; B8DUG2; -.
DR   STRING; 442563.BLA_1356; -.
DR   EnsemblBacteria; ACL29641; ACL29641; BLA_1356.
DR   GeneID; 66533187; -.
DR   KEGG; bla:BLA_1356; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002456; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..366
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118290"
FT   REGION          298..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  39638 MW;  0859C2B9C3A0AD13 CRC64;
     MSSTRRMQIL RAVVEDYIRQ QEPIGSGALA AKHHLGVSPA TIRNDMAALE DEGYLTQPHT
     SAGRIPTEKG YRYFVNSLST PIPLTAEQRE SISSALSGSA SLQDTLQRAA RILSTITGQY
     AMVSAPSLSR SLMRHVELLP LAAHTLLLVT ITETGRVVQR LVSTDTLPNT EQTQCICETI
     NTHCRLLTFR QCAQSIRTLP TDSEGGFTPQ LRDAIAAVFS DMENEERPNE LFTSGAASLT
     HQHIDAASLA PLFDALEEQV VLMRLMYDLT GQPGQEGVGV AIGSETHTPG LLHASVVSSG
     YGQSSTPSAN VEHEEYDTGT KPTMPIAVIG SIGPTHMNYA VTMAAVHAVS RYLTEFLRVG
     HNGWQE