ID   HRCA_BIFAA              Reviewed;         375 AA.
AC   A1A1M6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BAD_0828;
OS   Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 /
OS   E194a).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=367928;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15703 / DSM 20083 / NCTC 11814 / E194a;
RA   Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S.,
RA   Tanaka K., Watanabe K.;
RT   "Bifidobacterium adolescentis complete genome sequence.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP009256; BAF39609.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1A1M6; -.
DR   SMR; A1A1M6; -.
DR   STRING; 1680.BADO_0881; -.
DR   DNASU; 4556181; -.
DR   EnsemblBacteria; BAF39609; BAF39609; BAD_0828.
DR   KEGG; bad:BAD_0828; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000008702; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..375
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010379"
FT   REGION          307..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  39943 MW;  83FB665FA4F92C12 CRC64;
     MAQSRRMLVL RAVVEDYIRS QEPVGSTTLT RDHDLGVSSA TVRNDMAALE DEGYLIQPHT
     SAGRVPTEKG YRYFVDRLAT VVPLSEAQRR GINSFLSGSV NLQDTLQRAA RLLAQITGQV
     AVVAAPSLSK STLRHIEIVP VSINTLLAVV ITDTGRVAQH ILNVTKLPDV TTLTHLTNEI
     NTQCSGVSLT RTADCVRQMG ARKEYHAIST LAETLAQAFD GMADDERASE LYMAGTSRLA
     HQRTVADLAP LFDALEEQVV LMKLMSSLSE TTQSDGVGVA IGSETHTPGL LHASVVTSGY
     GRTSAAATDG ATHAAASSQT ENQSGDDTRQ AGEPVAFVGS IGPTHMDYAA TMAAVRAVAR
     YLTAFLAHDE GQPAD