ID   HRCA_BIFLO              Reviewed;         372 AA.
AC   Q8G6C7;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BL0718;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE014295; AAN24536.1; -; Genomic_DNA.
DR   RefSeq; NP_695900.1; NC_004307.2.
DR   RefSeq; WP_011068110.1; NC_004307.2.
DR   AlphaFoldDB; Q8G6C7; -.
DR   SMR; Q8G6C7; -.
DR   STRING; 206672.BL0718; -.
DR   EnsemblBacteria; AAN24536; AAN24536; BL0718.
DR   KEGG; blo:BL0718; -.
DR   PATRIC; fig|206672.9.peg.416; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q8G6C7; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..372
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182453"
FT   REGION          300..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  39456 MW;  04D716982CD1437E CRC64;
     MTQSRRMLVL RAVVEDYIRS QEPVGSTSLT RDHDLGVSSA TIRNDMAALE DEGYLIQPHT
     SAGRVPTEKG YRYFVDRLAT VVPLSEAQRR GINSFLSGSV SLKDALQRSA RLLSEITGQV
     AVVASPSLAK ATLRHVEMVP VAMTTLLAVV ITDTGRVAQH GLTIASMPAV DEINRLSNTV
     NEQCDGLSLS KSAETVRSIA ASAGYESVRG VADTLADAFE SMALDERANE LYMSGTSHLA
     HSRSLADLAP LFDALEEQVV LMKLMSNLSE ETNASGVGVA IGSEMHTPGL LHASVVSSGY
     GRSGAAGEPA GNDPVGEPET ESETESQTND TEPIAFVGSI GPTHMDYAAT MAAVRAVARY
     LTAFLSEGRT QD