ID   HRCA_BIFLS              Reviewed;         372 AA.
AC   B7GQV7; E8MJI3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Blon_1097, BLIJ_1122;
OS   Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM
OS   1222 / NCTC 11817 / S12).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=391904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12;
RX   PubMed=19033196; DOI=10.1073/pnas.0809584105;
RA   Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R.,
RA   Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P.,
RA   Richardson P.M., Mills D.A.;
RT   "The genome sequence of Bifidobacterium longum subsp. infantis reveals
RT   adaptations for milk utilization within the infant microbiome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12;
RX   PubMed=21270894; DOI=10.1038/nature09646;
RA   Fukuda S., Toh H., Hase K., Oshima K., Nakanishi Y., Yoshimura K., Tobe T.,
RA   Clarke J.M., Topping D.L., Suzuki T., Taylor T.D., Itoh K., Kikuchi J.,
RA   Morita H., Hattori M., Ohno H.;
RT   "Bifidobacteria can protect from enteropathogenic infection through
RT   production of acetate.";
RL   Nature 469:543-547(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001095; ACJ52187.1; -; Genomic_DNA.
DR   EMBL; AP010889; BAJ68710.1; -; Genomic_DNA.
DR   RefSeq; WP_012577445.1; NZ_JDTT01000017.1.
DR   AlphaFoldDB; B7GQV7; -.
DR   SMR; B7GQV7; -.
DR   PRIDE; B7GQV7; -.
DR   EnsemblBacteria; ACJ52187; ACJ52187; Blon_1097.
DR   KEGG; bln:Blon_1097; -.
DR   KEGG; blon:BLIJ_1122; -.
DR   PATRIC; fig|391904.8.peg.1120; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001360; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..372
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118291"
FT   REGION          296..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  39558 MW;  3D0F1AB87DADE635 CRC64;
     MTQSRRMLVL RAVVEDYIRS QEPVGSTSLT RDHDLGVSSA TIRNDMAALE DEGYLIQPHT
     SAGRVPTEKG YRYFVDRLAT VVPLSEAQRR GINSFLSGSV SLKDALQRSA RLLSEITGQV
     AVVTSPSLAK ATLRHVEMVP VAMTTLLAVV ITDTGRVAQH GLTIASMPAV DEINRLSNTV
     NEQCVGLSLS KSAETVRSIA ASAGYESVRG VADALADAFE SMALDERANE LYMSGTSHLA
     HSRSLTDLAP LFDALEEQVV LMKLMSNLSE ETNASGVGVA IGSEMHTPGL LHASVVSSGY
     GRSGEAGEPA GNDPVGEPET ESETESQTND MEPIAFVGSI GPTHMDYAAT MAAVRAVARY
     LTAFLSEGRT QD