HRCA_BORBR
ID HRCA_BORBR Reviewed; 334 AA.
AC Q7WGH9;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BB3939;
OS Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS (Alcaligenes bronchisepticus).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX640449; CAE34302.1; -; Genomic_DNA.
DR RefSeq; WP_003814090.1; NC_002927.3.
DR AlphaFoldDB; Q7WGH9; -.
DR SMR; Q7WGH9; -.
DR STRING; 257310.BB3939; -.
DR DNASU; 2661350; -.
DR EnsemblBacteria; CAE34302; CAE34302; BB3939.
DR GeneID; 56477576; -.
DR GeneID; 66437516; -.
DR KEGG; bbr:BB3939; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_4; -.
DR OMA; DYPGTMG; -.
DR OrthoDB; 1510750at2; -.
DR Proteomes; UP000001027; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..334
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182454"
SQ SEQUENCE 334 AA; 36657 MW; 9D709819E2172283 CRC64;
MDDRARALLK ALIERYIADG QPVGSRTLSK VFDLSPATIR NVMADLEELG LIHSPHTSAG
RVPTPRGYRM FVDSLLAVRA YQFEPAHIGE LLPVSEPSRA VNAAAALLSN LTQFAGVVLT
PKRTQIFRQI EFIRLSDKRV LLIIVTPEGD VQNRILSAQR DYTEAELLEA GNFFNVHFSG
KSFDAVRRTL STELAQLRDD ISRLMQAAVE AGAEAADDGE AVVISGERKL LDVTDIASDM
DRLRKMFSLF EKKTDLLQLL DVSSRAQGVQ IYIGGDSQLV PMEEVSVITA PYGVDGKVIG
TLGVIGPTRM AYERVIPIVD ITARLLSNAL SHNQ