ID   HRCA_BRADU              Reviewed;         362 AA.
AC   Q9REF2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=blr0675;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 110spc4;
RX   PubMed=10613857; DOI=10.1128/jb.182.1.14-22.2000;
RA   Minder A.C., Fischer H.-M., Hennecke H., Narberhaus F.;
RT   "Role of HrcA and CIRCE in the heat shock regulatory network of
RT   Bradyrhizobium japonicum.";
RL   J. Bacteriol. 182:14-22(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; Y09633; CAB60664.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC45940.1; -; Genomic_DNA.
DR   RefSeq; NP_767315.1; NC_004463.1.
DR   RefSeq; WP_011083502.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q9REF2; -.
DR   SMR; Q9REF2; -.
DR   STRING; 224911.27348924; -.
DR   PRIDE; Q9REF2; -.
DR   EnsemblBacteria; BAC45940; BAC45940; BAC45940.
DR   GeneID; 64020537; -.
DR   KEGG; bja:blr0675; -.
DR   PATRIC; fig|224911.44.peg.44; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   InParanoid; Q9REF2; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q9REF2; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182457"
SQ   SEQUENCE   362 AA;  39166 MW;  6AEF9B814743331A CRC64;
     MAHHDPIHLI APRAGLAQLN ERSRDIFRQI VESYLATGEP VGSRNISRLI AMPLSPASVR
     NVMADLEQLG LIYAPHTSAG RLPTELGLRF FVDALMQVGD LNDAERQSIQ SQLTSVGQAQ
     SVEAALDQAL TRLSGLTRAA AVVLTPKSNA RLKHIEFVRL EPEKALVILV GEDGQVENRV
     LTLPPGVPSS AITEAGNFLN SRIRGRTLAE ARLELETALG EARAELDQLT QKVISAGIAS
     WSGGENEDRQ LIVRGHANLL EDLHALEDLE RVRLLFDDLE TKRGVIDLLG RAETAEGVRI
     FIGSENKLFS LSGSSTIISP YRDAAGHIVG VLGVIGPTRL NYARVIPTVD YAARIVSRLL
     GG