AP1S1_BOVIN
ID AP1S1_BOVIN Reviewed; 157 AA.
AC Q1JQ98;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=AP-1 complex subunit sigma-1A;
DE AltName: Full=Adaptor protein complex AP-1 subunit sigma-1A;
DE AltName: Full=Adaptor-related protein complex 1 subunit sigma-1A;
DE AltName: Full=Clathrin assembly protein complex 1 sigma-1A small chain;
DE AltName: Full=Clathrin coat assembly protein AP19;
DE AltName: Full=Golgi adaptor HA1/AP1 adaptin sigma-1A subunit;
DE AltName: Full=HA1 19 kDa subunit;
DE AltName: Full=Sigma 1a subunit of AP-1 clathrin;
DE AltName: Full=Sigma-adaptin 1A;
DE AltName: Full=Sigma1A-adaptin;
GN Name=AP1S1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that
CC plays a role in protein sorting in the late-Golgi/trans-Golgi network
CC (TGN) and/or endosomes. The AP complexes mediate both the recruitment
CC of clathrin to membranes and the recognition of sorting signals within
CC the cytosolic tails of transmembrane cargo molecules (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is a heterotetramer composed
CC of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit
CC AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small
CC adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}.
CC Note=Component of the coat surrounding the cytoplasmic face of coated
CC vesicles located at the Golgi complex. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000305}.
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DR EMBL; BC116132; AAI16133.1; -; mRNA.
DR RefSeq; NP_001070578.1; NM_001077110.1.
DR RefSeq; XP_010817909.1; XM_010819607.2.
DR AlphaFoldDB; Q1JQ98; -.
DR SMR; Q1JQ98; -.
DR STRING; 9913.ENSBTAP00000019237; -.
DR PaxDb; Q1JQ98; -.
DR PRIDE; Q1JQ98; -.
DR Ensembl; ENSBTAT00000019237; ENSBTAP00000019237; ENSBTAG00000014468.
DR GeneID; 768053; -.
DR KEGG; bta:768053; -.
DR CTD; 1174; -.
DR VEuPathDB; HostDB:ENSBTAG00000014468; -.
DR VGNC; VGNC:25981; AP1S1.
DR eggNOG; KOG0934; Eukaryota.
DR GeneTree; ENSGT00970000193372; -.
DR HOGENOM; CLU_061221_1_3_1; -.
DR InParanoid; Q1JQ98; -.
DR OMA; MIHFFIL; -.
DR OrthoDB; 1307450at2759; -.
DR TreeFam; TF312921; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000014468; Expressed in temporal cortex and 107 other tissues.
DR ExpressionAtlas; Q1JQ98; baseline.
DR GO; GO:0030121; C:AP-1 adaptor complex; IEA:InterPro.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd14831; AP1_sigma; 1.
DR InterPro; IPR044733; AP1_sigma.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; PTHR11753; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 2: Evidence at transcript level;
KW Coated pit; Cytoplasmic vesicle; Golgi apparatus; Membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..157
FT /note="AP-1 complex subunit sigma-1A"
FT /id="PRO_0000283804"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P61966"
SQ SEQUENCE 157 AA; 18602 MW; D46863170960D056 CRC64;
MRFMLLFSRQ GKLRLQKWYL ATSDKERKKM VRELMQVVLA RKPKMCSFLE WRDLKVVYKR
YASLYFCCAI EGQDNELITL ELIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLMGG
DVQDTSKKSV LKAIEQADLL QEEDESPRSV LEEMGLA
