ID   HRCA_BRASO              Reviewed;         362 AA.
AC   A4YJR2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BRADO0172;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CU234118; CAL74138.1; -; Genomic_DNA.
DR   RefSeq; WP_011923430.1; NC_009445.1.
DR   AlphaFoldDB; A4YJR2; -.
DR   SMR; A4YJR2; -.
DR   STRING; 114615.BRADO0172; -.
DR   EnsemblBacteria; CAL74138; CAL74138; BRADO0172.
DR   KEGG; bra:BRADO0172; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   BioCyc; BSP114615:BRADO_RS00825-MON; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010381"
SQ   SEQUENCE   362 AA;  39048 MW;  711A5B9CDC44F0B5 CRC64;
     MAHHDPINLM TPPAGLAQLN ERSREIFRQI VESYLATGEP VGSRNISRLI AVPLSPASVR
     NVMADLEQLG LIYAPHTSAG RLPTEAGLRF FVDALMQVGD MTEAERQSIQ SQLAAVGRAQ
     SVEAALDEAL TRLSGLTRAA AVVLTAKSNT RLKHIEFVRL EPEQALVVLV GEDGQVENRV
     LTLPPGVPSS ALTEASNFLN ARIRGRTLAE ARLELETALA QDRAELDQLT QKVIAAGVAS
     WSGGDSDDRQ LIVRGHANLL EDLHALDDLE RVRRLFDDLE TKRGVVDLLG RAESAEGVRI
     FIGSENKLFS LSGSSTIVSP YSDATGRIVG VLGVIGPTRL NYARVIPTVD YAARLLSRLM
     GG