ID   HRCA_BRUME              Reviewed;         356 AA.
AC   P64396; Q8YEV1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=BMEI1776;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL52957.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008917; AAL52957.1; ALT_INIT; Genomic_DNA.
DR   PIR; AB3474; AB3474.
DR   RefSeq; WP_002965420.1; NZ_CP007763.1.
DR   AlphaFoldDB; P64396; -.
DR   SMR; P64396; -.
DR   STRING; 224914.BMEI1776; -.
DR   EnsemblBacteria; AAL52957; AAL52957; BMEI1776.
DR   GeneID; 45051313; -.
DR   GeneID; 55589960; -.
DR   KEGG; bme:BMEI1776; -.
DR   PATRIC; fig|224914.52.peg.1806; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; P64396; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..356
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182458"
SQ   SEQUENCE   356 AA;  39094 MW;  1F72BCC0E77A2FB7 CRC64;
     MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP ATIRNVMSDL
     EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER SSIEAQVRAA GTSNSVESVL
     TEASQVLSGL SRGAGLVLTN KTDVALKHIE FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG
     ISTSQLIEAS NFLNAHIHGH TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA
     DQPARLIVRG RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE
     NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI VSRLLR