ID   HRCA_BRUSU              Reviewed;         356 AA.
AC   P64397; G0KBE5; Q8YEV1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=BR0172, BS1330_I0172;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN29125.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AEM17537.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014291; AAN29125.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002997; AEM17537.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002965420.1; NZ_KN046804.1.
DR   AlphaFoldDB; P64397; -.
DR   SMR; P64397; -.
DR   EnsemblBacteria; AEM17537; AEM17537; BS1330_I0172.
DR   GeneID; 45051313; -.
DR   GeneID; 55589960; -.
DR   KEGG; bms:BR0172; -.
DR   KEGG; bsi:BS1330_I0172; -.
DR   PATRIC; fig|204722.22.peg.1660; -.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   PhylomeDB; P64397; -.
DR   Proteomes; UP000007104; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..356
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182459"
SQ   SEQUENCE   356 AA;  39094 MW;  1F72BCC0E77A2FB7 CRC64;
     MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP ATIRNVMSDL
     EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER SSIEAQVRAA GTSNSVESVL
     TEASQVLSGL SRGAGLVLTN KTDVALKHIE FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG
     ISTSQLIEAS NFLNAHIHGH TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA
     DQPARLIVRG RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE
     NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI VSRLLR