ID   HRCA_BURA4              Reviewed;         340 AA.
AC   B1YTJ4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=BamMC406_0663;
OS   Burkholderia ambifaria (strain MC40-6).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=398577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC40-6;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA   Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001025; ACB63159.1; -; Genomic_DNA.
DR   RefSeq; WP_011656033.1; NC_010551.1.
DR   AlphaFoldDB; B1YTJ4; -.
DR   SMR; B1YTJ4; -.
DR   EnsemblBacteria; ACB63159; ACB63159; BamMC406_0663.
DR   GeneID; 44691324; -.
DR   GeneID; 60994325; -.
DR   KEGG; bac:BamMC406_0663; -.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001680; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092795"
SQ   SEQUENCE   340 AA;  37420 MW;  77F2E5BD097FA5B1 CRC64;
     MLDPRARTLL KTLIERYIAD GQPVGSRTLS RYSGLELSPA TIRNVMSDLE ELGLVSSPHT
     SAGRVPTPRG YRLFVDTMLT VETPIDAEAV ARQVQHTLQA GEPQQRVVAA AASVLSNLSQ
     FAGVVLTPRR SHVFKQIEFM RLSDKRILLI IVTPEGDVQN RMLATPRDYS PSQLTEASNY
     INAHFAGLSF DEVRRRLRDE IDQLRGDMTT LMHAAVTAST EVPDTEDTVL ISGERNLLEV
     ADLSSDMARL RKLFDVFDQK TGLLQLLDVS SHAQGVQIFI GGESTLVPIE EMSVVTAPYE
     VNGQIVGTLG VIGPTRMAYN RVIPIVDITA RLLSLTLSQQ