ID   AP1S1_DICDI             Reviewed;         156 AA.
AC   Q54WW3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=AP-1 complex subunit sigma-1;
DE   AltName: Full=Adaptor protein complex AP-1 subunit sigma-1A;
DE   AltName: Full=Adaptor-related protein complex 1 subunit sigma-1A;
DE   AltName: Full=Clathrin assembly protein complex 1 sigma-1A small chain;
DE   AltName: Full=Sigma 1a subunit of AP-1 clathrin;
DE   AltName: Full=Sigma-adaptin 1A;
DE   AltName: Full=Sigma1A-adaptin;
GN   Name=ap1s1; ORFNames=DDB_G0279359;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that
CC       plays a role in protein sorting in the trans-Golgi network (TGN) and
CC       endosomes. The AP complexes mediate the recruitment of clathrin to
CC       membranes and the recognition of sorting signals within the cytosolic
CC       tails of transmembrane cargo molecules. Also involved in early steps of
CC       phagocytosis and macropinocytosis.
CC   -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is a heterotetramer composed
CC       of two large adaptins (gamma-type subunit and beta-type subunit), a
CC       medium adaptin (mu-type subunit) and a small adaptin (sigma-type
CC       subunit). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cytoplasmic
CC       vesicle, clathrin-coated vesicle membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000030; EAL67828.1; -; Genomic_DNA.
DR   RefSeq; XP_641814.1; XM_636722.1.
DR   AlphaFoldDB; Q54WW3; -.
DR   SMR; Q54WW3; -.
DR   STRING; 44689.DDB0232337; -.
DR   PaxDb; Q54WW3; -.
DR   EnsemblProtists; EAL67828; EAL67828; DDB_G0279359.
DR   GeneID; 8622010; -.
DR   KEGG; ddi:DDB_G0279359; -.
DR   dictyBase; DDB_G0279359; ap1s1.
DR   eggNOG; KOG0934; Eukaryota.
DR   HOGENOM; CLU_061221_0_0_1; -.
DR   InParanoid; Q54WW3; -.
DR   OMA; FLLCFNR; -.
DR   PhylomeDB; Q54WW3; -.
DR   Reactome; R-DDI-432720; Lysosome Vesicle Biogenesis.
DR   PRO; PR:Q54WW3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0030121; C:AP-1 adaptor complex; IEA:InterPro.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14831; AP1_sigma; 1.
DR   InterPro; IPR044733; AP1_sigma.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..156
FT                   /note="AP-1 complex subunit sigma-1"
FT                   /id="PRO_0000328670"
SQ   SEQUENCE   156 AA;  18382 MW;  11E961F5C319492D CRC64;
     MIHFLLCFNR QSKVRLSKFY STYTPTEKNR ATREVMNQVL SRSPKFCNFV QWREFTIVYQ
     RFASLFFVMV TDSTDNELVT LESIQRFVVV LDIVFGNICE LDLIYEFQRA YQVLDEFLLT
     GHLQESSSKE ILRAINDAEG MEKSLLVAEV LDQHFL