HRCA_BURM1
ID HRCA_BURM1 Reviewed; 340 AA.
AC A9AGC4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN OrderedLocusNames=Bmul_2639, BMULJ_00599;
OS Burkholderia multivorans (strain ATCC 17616 / 249).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=395019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia multivorans ATCC
RT 17616.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E.,
RA Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N.,
RA Hattori M., Tsuda M.;
RT "Complete genome sequence of Burkholderia multivorans ATCC 17616.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP000868; ABX16323.1; -; Genomic_DNA.
DR EMBL; AP009385; BAG42563.1; -; Genomic_DNA.
DR RefSeq; WP_006416966.1; NC_010804.1.
DR AlphaFoldDB; A9AGC4; -.
DR SMR; A9AGC4; -.
DR STRING; 395019.Bmul_2639; -.
DR EnsemblBacteria; BAG42563; BAG42563; BMULJ_00599.
DR GeneID; 66525559; -.
DR KEGG; bmj:BMULJ_00599; -.
DR KEGG; bmu:Bmul_2639; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_4; -.
DR OMA; DYPGTMG; -.
DR Proteomes; UP000008815; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..340
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000092798"
SQ SEQUENCE 340 AA; 37268 MW; 4BF56DC7C1A8597A CRC64;
MLDPRARTLL KTLIERYIAD GQPVGSRTLS RYSGLELSPA TIRNVMSDLE ELGLVSSPHT
SAGRVPTPRG YRLFVDTMLT VETPIDAAAV ARQVQSTLQA GEPQQKVVAA AASVLSNLSQ
FAGVVLTPRR SHVFKQIEFM RLSEKRILLI IVTPEGDVQN RMLATPRDYS PSQLTEASNY
INAHFAGLSF DEVRRRLRDE IDQLRGDMTA LMHAAVTAST EVPDTEDTVL ISGERNLLEV
ADLSSDMARL RKLFDVFDQK TGLLQLLDVS SHAQGVQIFI GGESTLVPIE EMSVVTAPYE
VNGKIVGTLG VIGPTRMAYN RVIPIVDITA RLLSLTLSQQ
