ID   HRCA_BURM7              Reviewed;         340 AA.
AC   A3MNA5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=BMA10247_2212;
OS   Burkholderia mallei (strain NCTC 10247).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320389;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 10247;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000548; ABO07314.1; -; Genomic_DNA.
DR   RefSeq; WP_004194248.1; NZ_CP007802.1.
DR   AlphaFoldDB; A3MNA5; -.
DR   SMR; A3MNA5; -.
DR   GeneID; 56594679; -.
DR   KEGG; bmaz:BM44_1031; -.
DR   KEGG; bmn:BMA10247_2212; -.
DR   PATRIC; fig|320389.8.peg.1151; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002284; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010385"
SQ   SEQUENCE   340 AA;  37426 MW;  921822802870379C CRC64;
     MLDPRARTLL KTLIERYIAD GQPVGSRTLS RYSGLELSPA TIRNVMSDLE ELGLVSSPHT
     SAGRVPTPRG YRLFVDTMLT VESPIDSDAV TRLVQTTLQA GEPQQRVVAA AASVLSNLSQ
     FAGVVLTPRR SHVFKQIEFL RLSDKRILLI IVTPEGDVQN RMIATQRDYA PAQLTEASNY
     INAHFAGLSF DEVRRRLREE IDQLRGDMTA LMHAAVTAST EEPDDEETVL ISGERNLLEV
     ADLSSDMARL RKLFDVFDQK TSLLQLLDVS SHAQGVQIFI GGESTLVPID EMSVVTAPYE
     VNGKIVGTLG VIGPTRMAYN RVIPIVDITA RLLSLTLSQQ