ID   HRCA_CAMJE              Reviewed;         264 AA.
AC   Q9PPG2; Q0PAD3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Cj0757;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AL111168; CAL34885.1; -; Genomic_DNA.
DR   PIR; E81346; E81346.
DR   RefSeq; WP_010891884.1; NC_002163.1.
DR   RefSeq; YP_002344164.1; NC_002163.1.
DR   AlphaFoldDB; Q9PPG2; -.
DR   IntAct; Q9PPG2; 6.
DR   STRING; 192222.Cj0757; -.
DR   PaxDb; Q9PPG2; -.
DR   PRIDE; Q9PPG2; -.
DR   EnsemblBacteria; CAL34885; CAL34885; Cj0757.
DR   GeneID; 905067; -.
DR   KEGG; cje:Cj0757; -.
DR   PATRIC; fig|192222.6.peg.745; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_091026_0_0_7; -.
DR   OMA; LCVGKLE; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..264
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182462"
SQ   SEQUENCE   264 AA;  30935 MW;  CF1E4C9DA2A05BFF CRC64;
     MMKSRDKKDL ILESIIQTYL LDNAPIGSNE LNSNLCIPAS TIRVYLKRLS DEGLITQLHI
     SSGRIPTILT MQNYWQNFWE KEQDKNIHIK NESFLKELSK EFEIYCLVYG GRSLVLKEVL
     DLNTKFIVLD FEDEELVLKY EKEAWNFLQS LIGLDLSSIE KIALRVHFID LVEKIASLRQ
     NLICYRSNEE RAYQIYQNDE FVKLLDCQIH RHFKESLEFE PLFKEGFMGL KVDAQFLGED
     VNIILAGSVY TDYKKILQYI KEAA