HRCA_CARHZ
ID HRCA_CARHZ Reviewed; 341 AA.
AC Q3AF11;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CHY_0412;
OS Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS Z-2901).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Carboxydothermus.
OX NCBI_TaxID=246194;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT "Life in hot carbon monoxide: the complete genome sequence of
RT Carboxydothermus hydrogenoformans Z-2901.";
RL PLoS Genet. 1:563-574(2005).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP000141; ABB14801.1; -; Genomic_DNA.
DR RefSeq; WP_011343349.1; NC_007503.1.
DR AlphaFoldDB; Q3AF11; -.
DR SMR; Q3AF11; -.
DR STRING; 246194.CHY_0412; -.
DR EnsemblBacteria; ABB14801; ABB14801; CHY_0412.
DR KEGG; chy:CHY_0412; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OMA; DYPGTMG; -.
DR OrthoDB; 1510750at2; -.
DR Proteomes; UP000002706; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..341
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000010392"
SQ SEQUENCE 341 AA; 38513 MW; E8B5CA01001D0067 CRC64;
MIDERKRKIL MAIVQDYIST AEPVGSRTIA KKYDLGISPA TIRNEMADLE EMGYLEQPHT
SAGRIPSVLG YRYYVDYLME KPSLSREEEE FIRKVYEDKI NSIGDLLEKT GKVLSSLTRY
TAVVLSPEAG KVPLKHLQLV LLQPGKVLLI IVLEDGTLHH RAFEVPGDIT AQDLEKVSAI
LNAKLYGVNP EKIRYSLIKE IYYELAQHQN LINITLELIS NLNQDNQEHK IILGGLINLF
NQPEFKNVEK VKTLLSILEQ EEKIREIFSQ LNVGVNVKIG SELNLKEIED CSMIAAGYFS
YGNSVGFIGV LGPTRMEYAK TVATVEFLSK YLSEIIGNKN F