ID   HRCA_CAUSK              Reviewed;         358 AA.
AC   B0T368;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Caul_0166;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter; unclassified Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000927; ABZ69303.1; -; Genomic_DNA.
DR   RefSeq; WP_012284261.1; NC_010338.1.
DR   AlphaFoldDB; B0T368; -.
DR   SMR; B0T368; -.
DR   STRING; 366602.Caul_0166; -.
DR   EnsemblBacteria; ABZ69303; ABZ69303; Caul_0166.
DR   KEGG; cak:Caul_0166; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..358
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075283"
SQ   SEQUENCE   358 AA;  38404 MW;  1EC5639D8584203D CRC64;
     MTQLFSGFSA QTPSLTDLDG RARDIFRRVV ESYLETGEPV GSRTISRGGV QLSPASIRNT
     MQDLAQLGLL DAPHSSAGRI PTHAGLRMFV DGLLEVGDIG EEERRTIESR LFAHGRSFEE
     AMGEASAILS GLAGGAGIVV TPVREGGVKH VEFVALGADQ ALAIMVFDDG TVENRLMKRS
     AGVTPASLQE ASNFLNARLR GRTLNEAKTE MAAELDTARR ELDATAARLV EDGLAAWSGG
     DDPDRALIVR GRANLLADAS AREDLERVRR LFDDLEQKGQ LIGLLDDVRS AEGVRIFIGA
     ETRLFSLSGS SLIAAPYMSG RQKVLGAIGV IGPTRLNYAR VIPLVDYTAR VLGRMMDG