ID   HRCA_CAUVC              Reviewed;         358 AA.
AC   P0CAV3; P54305;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CC_0153;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE005673; AAK22140.1; -; Genomic_DNA.
DR   PIR; H87267; H87267.
DR   RefSeq; NP_418972.1; NC_002696.2.
DR   RefSeq; WP_010918042.1; NC_002696.2.
DR   AlphaFoldDB; P0CAV3; -.
DR   SMR; P0CAV3; -.
DR   STRING; 190650.CC_0153; -.
DR   EnsemblBacteria; AAK22140; AAK22140; CC_0153.
DR   KEGG; ccr:CC_0153; -.
DR   PATRIC; fig|190650.5.peg.150; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; CAULO:CC0153-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..358
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182463"
SQ   SEQUENCE   358 AA;  38294 MW;  D38BC3A814E2C9E7 CRC64;
     MTQLFPGPIV RTPGLAELDA RARDIFRRVV ESYLETGEPV GSRTISKGGV ALSPASIRNT
     MQDLAQLGLL DAPHTSAGRM PTHAGLRMFV DGFLEVGDVA EQEKRAIEAR LAVKGRSFEE
     ALAEASSILS GLAGGAGIVV TPVREGGVKH VEFVPLGGGQ VLAVMVFEDG QVENRLMRQA
     PGVTPSALQE ASNFLNARLR GRTLTEARTE MGGELDAARR QLNETAARLV EDGLAAWSGG
     EGDARSLIVR GQANLLADAR AREDIDRVRQ LFDDLSRRAQ LIGLLDDVRD AEGVRIYIGA
     ETRLFSLSGS SVIAAPYMTG RQKVLGAIGV IGPARLNYAR VIPLVDYTAR VLGRMMDG