ID   HRCA_CAUVN              Reviewed;         358 AA.
AC   B8GXP3; P54305;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CCNA_00152;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8606155; DOI=10.1128/jb.178.7.1829-1841.1996;
RA   Roberts R.C., Toochinda C., Avedissian M., Baldini R.L., Gomes S.L.,
RA   Shapiro L.;
RT   "Identification of a Caulobacter crescentus operon encoding hrcA, involved
RT   in negatively regulating heat-inducible transcription, and the chaperone
RT   gene grpE.";
RL   J. Bacteriol. 178:1829-1841(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; U33324; AAB01515.1; -; Genomic_DNA.
DR   EMBL; CP001340; ACL93619.1; -; Genomic_DNA.
DR   RefSeq; WP_012639892.1; NC_011916.1.
DR   RefSeq; YP_002515527.1; NC_011916.1.
DR   AlphaFoldDB; B8GXP3; -.
DR   SMR; B8GXP3; -.
DR   PRIDE; B8GXP3; -.
DR   EnsemblBacteria; ACL93619; ACL93619; CCNA_00152.
DR   GeneID; 7332406; -.
DR   KEGG; ccs:CCNA_00152; -.
DR   PATRIC; fig|565050.3.peg.151; -.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   PhylomeDB; B8GXP3; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..358
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000378294"
SQ   SEQUENCE   358 AA;  38266 MW;  38D7D61D94D3B13C CRC64;
     MTQLFPGPIV RTPGLAELDA RARDIFRRVV ESYLETGEPV GSRTISKGGV ALSPASIRNT
     MQDLAQLGLL DAPHTSAGRM PTHAGLRMFV DGFLEVGDVA EQEKRAIEAR LAVKGRSFEE
     ALAEASSILS GLAGGAGIVV TPVREGGVKH VEFVPLGGGQ VLAVMVFEDG QVENRLMRQA
     PGVTPSALQE ASNFLNARLR GRTLTEARTE MGGELDAARR QLNETAARLV EDGLAAWSGG
     EGDARSLIVR GQANLLADAR AREDIDRVRQ LFDDLEQKGQ LIGLLDDVRD AEGVRIYIGA
     ETRLFSLSGS SVIAAPYMTG RQKVLGAIGV IGPARLNYAR VIPLVDYTAR VLGRMMDG