ID   HRCA_CHLAA              Reviewed;         372 AA.
AC   A9WEX3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Caur_2076;
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl;
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000909; ABY35288.1; -; Genomic_DNA.
DR   RefSeq; WP_012257942.1; NC_010175.1.
DR   RefSeq; YP_001635677.1; NC_010175.1.
DR   AlphaFoldDB; A9WEX3; -.
DR   SMR; A9WEX3; -.
DR   STRING; 324602.Caur_2076; -.
DR   EnsemblBacteria; ABY35288; ABY35288; Caur_2076.
DR   KEGG; cau:Caur_2076; -.
DR   PATRIC; fig|324602.8.peg.2356; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   InParanoid; A9WEX3; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..372
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075284"
SQ   SEQUENCE   372 AA;  40955 MW;  74978B64F49DD5DD CRC64;
     MSGPLTERRQ MILKLVIQEF VDTATPVASE TLVRKYRLPV SSATVRNDMA ALEELGFLTH
     PHTSGGRIPT DAGYRFFVEN LMERTTLSPA EQRMIRHQFY QVRGELDQWV QLACAVLART
     AHNASVATAP RAEQLRFKSL ELIAIHETMA LAVIVFHGGI VKQQTLPIEP GRTPEDLRRA
     AGLVSDLLAD ATLSRAEELA AIATFNGVPL SEFERTLVDL VVRAMSVFEE QAQEQIYSDG
     ILEMLSQPEF LPASGRDDAE RAIERLRRTL EILKSGRGLS PLIPQALASG GVQVIIGGEH
     SEDTMRDYSV ILARYGVEGA LVGVLGVIGP TRMAYPRSIS TVRYIASLMT NLLADLYHVN
     TRPSDIEPAA EL