ID   HRCA_CHLAB              Reviewed;         386 AA.
AC   Q8GH81; Q5L6M6;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CAB239;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AB7;
RX   PubMed=12056482; DOI=10.1051/vetres:2002019;
RA   Hechard C., Grepinet O., Rodolakis A.;
RT   "Protection evaluation against Chlamydophila abortus challenge by DNA
RT   vaccination with a dnaK-encoding plasmid in pregnant and non-pregnant
RT   mice.";
RL   Vet. Res. 33:313-326(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF384685; AAN77257.1; -; Genomic_DNA.
DR   EMBL; CR848038; CAH63695.1; -; Genomic_DNA.
DR   RefSeq; WP_011096925.1; NC_004552.2.
DR   AlphaFoldDB; Q8GH81; -.
DR   SMR; Q8GH81; -.
DR   EnsemblBacteria; CAH63695; CAH63695; CAB239.
DR   KEGG; cab:CAB239; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..386
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182464"
SQ   SEQUENCE   386 AA;  44217 MW;  0A92B89541B5A2CB CRC64;
     MSKSWISKRE SKLLYILLTT TELYLKTGQP VGSKTLKEYE CSNLSTATIR NYFAELEAEG
     FLKKNHVSGG RIPTDLAFRY YVDHRADFLQ DDLPETTIHL LNQLPKESQN IVKDLQKASE
     LLGEALQLPT CFSSPRFEND SVTNIQLSLV DEQRVVVILS TEFGQIFTDT LWLAETSNYA
     SLKRIETFLQ NYLRKQPPSE TLSQKEEDLG MTLYNEVVVR YLTRYCNFSE EDLYQTGLSK
     LLKYDAFKDP DMLALGLSFF ESRCHMCKLL DIGMHRDRPT AFIGSELSDI FGTPNPHCAV
     ITTPYYMNRT PLGAFGVLGP INLPYREIYK TLTIFADKVK ESLTQSFYKF KLSFRRPCPS
     DPKLSKEPTL LARYSSIKLL PPKETS