ID   HRCA_CHLAD              Reviewed;         376 AA.
AC   B8G4T8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Cagg_2696;
OS   Chloroflexus aggregans (strain MD-66 / DSM 9485).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=326427;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MD-66 / DSM 9485;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chloroflexus aggregans DSM 9485.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001337; ACL25564.1; -; Genomic_DNA.
DR   RefSeq; WP_015941421.1; NC_011831.1.
DR   AlphaFoldDB; B8G4T8; -.
DR   SMR; B8G4T8; -.
DR   STRING; 326427.Cagg_2696; -.
DR   EnsemblBacteria; ACL25564; ACL25564; Cagg_2696.
DR   KEGG; cag:Cagg_2696; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002508; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..376
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118294"
SQ   SEQUENCE   376 AA;  41579 MW;  412BF9225A26925B CRC64;
     MSGPLTERRQ TILKLVIQEF VDTATPVASE TLVRKYRLPV SPATVRNDMA ALEELGFLTH
     PHTSGGRIPT DTGYRFFVEN LMERTSLSPA EQRMIRHQFY QVRGELDQWV QLACAVLART
     AHNASVATAP RAEQLRFKSL ELISIHETMA LAVIVFHGGI VKQQTLPVEP WRTPEDLRRA
     AGLVSDLLAD ATLTRVEELA TAATFNGIPL SDFERGLVDL VVRAMIAFEE QAQEQIYSDG
     LLEMLSQPEF SPASGRDDAE RVIERMRRTL EILKSGRGLG PLIPQALASG GVQVIIGGEH
     GEDTMRDYSV ILARYGVEGV IAGVLGVIGP TRMAYPRSIS TVRYIASLMN NLLAELYNVQ
     ARPSEGESEY KDEQHA