ID   HRCA_CHLCV              Reviewed;         386 AA.
AC   Q824B0;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CCA_00243;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE015925; AAP04994.1; -; Genomic_DNA.
DR   RefSeq; WP_011006212.1; NC_003361.3.
DR   AlphaFoldDB; Q824B0; -.
DR   SMR; Q824B0; -.
DR   STRING; 227941.CCA_00243; -.
DR   EnsemblBacteria; AAP04994; AAP04994; CCA_00243.
DR   KEGG; cca:CCA_00243; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..386
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182465"
SQ   SEQUENCE   386 AA;  44126 MW;  1E746E7600611652 CRC64;
     MSRSWISKRE SKILYILLTT TELYLKTGHP VGSKTLKEYE GSNLSTATIR NYFSELEAEG
     FLKKNHISGG RIPTDLAFRY YVDHCADCSQ DELPESTINL LNQLPEESQN IVKDLQKASE
     LLGEALQLPT CFSSPRFDND SVTNIQLSLV DEQRAVVILS TEFGQIFTDT LWLSEASNPA
     SLKRIEIFLQ SYVRKQSPME ILSQKEEDIG MTLYNEVVVR YLTRYCNFSE EDLYQTGLSK
     LLRYESFKDP DMLALGLSFF ENRRHMCKLL DIGMHRDRPT AFIGNELSDI FRTPNPQCAV
     ITIPYYMNRT PLGAFGVLGP VNLPYKEIFK TLTIFADKIK ASLTQSFYKF KLSFRRPCPS
     DPTLSKEPTL LARYSSIKLL PPKETS