ID   HRCA_CHLFF              Reviewed;         386 AA.
AC   Q253K3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CF0763;
OS   Chlamydia felis (strain Fe/C-56) (Chlamydophila felis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fe/C-56;
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H.,
RA   Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP006861; BAE81535.1; -; Genomic_DNA.
DR   RefSeq; WP_011458313.1; NC_007899.1.
DR   AlphaFoldDB; Q253K3; -.
DR   SMR; Q253K3; -.
DR   STRING; 264202.CF0763; -.
DR   KEGG; cfe:CF0763; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001260; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..386
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010394"
SQ   SEQUENCE   386 AA;  44160 MW;  5B6C158479E097C1 CRC64;
     MSRSWISKRE SKILYILLTT TELYLKTGQP VGSKTLKEYE CSNLSTATIR NYFSELESEG
     FLKKNHISGG RIPTDLAFRY YVDHCADFSQ SELPESTTRL LNQLPEESQN IVKDLQKALE
     ILGEALQLPT CFSSPRFEND SITNIQISLV DEQRVVVILS TEFGQVFTET LWLPETSSPA
     SVKRIETFLQ SYVRKQPPTE ILSQKEEDLG MTLYNEVVVR YLTRYCNFSE EDLYQTGLSK
     LLKYDAFKDP DTLALGLSFF ENRRHMCKLL DIGMHRDRPT AFIGNELSTI FGTPNPQCAV
     ITTPYYMNRT PLGAFGVLGP INLPYREIFQ TLTIFADKVK DSLTQSFYKF KLSFRRPCPS
     DPKLSKEPTL LARYSSIKLL PPKETS