ID   HRCA_CHLL2              Reviewed;         357 AA.
AC   B3EE33;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Clim_1693;
OS   Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 245 / NBRC 103803 / 6330;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T., Liu Z.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium limicola DSM 245.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001097; ACD90735.1; -; Genomic_DNA.
DR   RefSeq; WP_012466608.1; NC_010803.1.
DR   AlphaFoldDB; B3EE33; -.
DR   SMR; B3EE33; -.
DR   STRING; 290315.Clim_1693; -.
DR   EnsemblBacteria; ACD90735; ACD90735; Clim_1693.
DR   KEGG; cli:Clim_1693; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_10; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008841; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092801"
SQ   SEQUENCE   357 AA;  39828 MW;  E1CFEB54179A6B23 CRC64;
     MDSPELTLRE RQVLGIVIQS YVVSAAPVGS RYIARNYNLG LSDATIRNVM ADLEREGFIS
     QPHTSAGRVP TDKGYRYYVD LIMHVQRIND EEKRRIDADF GQLTCERKGT STEVLFSAAK
     VLGTISRQLS VVLSPAFSNA VFEKLDMVLL SSSRMMVILS IRSLFLRTIV MELDIEVSRQ
     MVDDVVAVLN ERLSGLTLVE IRRTLVVRLS DCTCDSALLD RIVRSSGELF DETPMIERLY
     ISGAEYIIDQ PEFKQPEKVR DLISMIEDKT SVAKLVDDAT AAVEAVKPQG MDVSITIGKE
     NIERKAGELT ILSTPYYVGD MVGKLGILGP TRMDYEHAVR VLNYMADCLS TTLSEVP