ID   HRCA_CHLMU              Reviewed;         392 AA.
AC   P54306;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=TC_0673;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MoPn;
RX   PubMed=8955323; DOI=10.1128/jb.178.23.6983-6990.1996;
RA   Tan M., Wong B., Engel J.N.;
RT   "Transcriptional organization and regulation of the dnaK and groE operons
RT   of Chlamydia trachomatis.";
RL   J. Bacteriol. 178:6983-6990(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; U52216; AAA97480.1; -; Genomic_DNA.
DR   EMBL; AE002160; AAF39494.1; -; Genomic_DNA.
DR   PIR; F81676; F81676.
DR   AlphaFoldDB; P54306; -.
DR   SMR; P54306; -.
DR   STRING; 243161.TC_0673; -.
DR   EnsemblBacteria; AAF39494; AAF39494; TC_0673.
DR   KEGG; cmu:TC_0673; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182466"
FT   CONFLICT        318
FT                   /note="L -> K (in Ref. 1; AAA97480)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   392 AA;  44965 MW;  B579B3D2D6AC2034 CRC64;
     MENRTEMSQL RASKKDSKIS HVLLMAIKLY LESGQPVGSK LLKETYCSDL SSATIRNYFA
     QLETDGFLRK NHISGGRIPT DLAFRYYADH CSPVLEQEEI SIIQQKLKEL PEYSKNIVKD
     LQKASEILSE ILQLPVCFSS PRFESDSVTN IQLVSIDDLR VVFVLSTEFG QLFTDVLWLP
     EQLPENSLKR IESFLQNYLR KHPSSVPLSQ KEEDLGMTLY NEVVVRYLTR YCHFSEEDLY
     QTGLSRLLKY EVFKDPETLA QGLSFFENRK HMCQLLNSHL HKKAPTTFIG RELSDIVGNA
     DPSCAVITVP YYMDRTPLGA FGVLGPMNLP YQQVFGTLSL FTERLKTILT QSFYKFKLSF
     RRPCPTDPRC SQKPAELTRR SSIKLLPAKE LT