ID   3SX1_MICDM              Reviewed;          66 AA.
AC   C0HLK5;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Clarkitoxin-I-Mdum {ECO:0000303|PubMed:31557485};
DE   AltName: Full=Dumertoxin-1 {ECO:0000303|PubMed:31557485};
OS   Micrurus dumerilii (Coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=1337871 {ECO:0000303|PubMed:31557485};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom {ECO:0000303|PubMed:31557485};
RX   PubMed=31557485; DOI=10.1016/j.toxicon.2019.09.017;
RA   Rey-Suarez P., Saldarriaga-Cordoba M., Torres U., Marin-Villa M.,
RA   Lomonte B., Nunez V.;
RT   "Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus
RT   coral snake venoms: Phylogenetic relationships and characterization of
RT   Clarkitoxin-I-Mdum.";
RL   Toxicon 170:85-93(2019).
CC   -!- FUNCTION: No toxicity is observed upon intravenous or
CC       intracerebroventricular injection into mice. Has no cytotoxic activity
CC       towards C2C12 cells at 100 ug/ml. {ECO:0000269|PubMed:31557485}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31557485}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:31557485}.
CC   -!- MASS SPECTROMETRY: Mass=7537; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:31557485};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HLK5; -.
DR   SMR; C0HLK5; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..66
FT                   /note="Clarkitoxin-I-Mdum"
FT                   /id="PRO_0000450601"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        17..42
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        46..59
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        60..65
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
SQ   SEQUENCE   66 AA;  7544 MW;  C07D5FF85DB58E66 CRC64;
     RICDDSSIPF LRTPQLCPKG QDVCYKKTPI VKKFKWLQKK GCASSCPKDG FIKIFKIECC
     TKDNCI