ID   HRCA_CHLPB              Reviewed;         352 AA.
AC   B3EPC5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Cphamn1_0852;
OS   Chlorobium phaeobacteroides (strain BS1).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=331678;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BS1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium phaeobacteroides BS1.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001101; ACE03803.1; -; Genomic_DNA.
DR   RefSeq; WP_012474291.1; NC_010831.1.
DR   AlphaFoldDB; B3EPC5; -.
DR   SMR; B3EPC5; -.
DR   STRING; 331678.Cphamn1_0852; -.
DR   KEGG; cpb:Cphamn1_0852; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_10; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092803"
SQ   SEQUENCE   352 AA;  39777 MW;  A39894D1C1F99900 CRC64;
     MMFHDLSERE RQVLSIIIQA YVMNASPVGS RYIARNYNLG LSDATIRNVM ADLEDAGYIS
     QPHTSAGRVP TDKGYRYYVD LIMRVQGIDD EEINRIDRNF RLLKYDPKDS ADILQAAAKV
     LGSISQQLSV VISPRLSNAL FERLDLVVLS SSRIMVVLSI QSLFVRTIVM ELSLEVSRQQ
     IDNVIDLLNQ RLSGLTLREI RNSISRRLAD CDKDRELLNM IVGSADNLFD DTPVLERLYI
     AGAEHIVNQP EFDQPQKVRD LVCMIEDKNR MVELLEKEGR VKPVTSSGMD VSISIGRENS
     ATTAEDFTVV TTPYYVGNTI GRLGVLGPKR MDYERVVRLV NYMADRLSHS LS