ID   HRCA_CHLPD              Reviewed;         357 AA.
AC   A1BHL3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Cpha266_1874;
OS   Chlorobium phaeobacteroides (strain DSM 266).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 266;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium phaeobacteroides DSM 266.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000492; ABL65890.1; -; Genomic_DNA.
DR   RefSeq; WP_011745697.1; NC_008639.1.
DR   AlphaFoldDB; A1BHL3; -.
DR   SMR; A1BHL3; -.
DR   STRING; 290317.Cpha266_1874; -.
DR   EnsemblBacteria; ABL65890; ABL65890; Cpha266_1874.
DR   KEGG; cph:Cpha266_1874; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_10; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008701; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010395"
SQ   SEQUENCE   357 AA;  39717 MW;  FF94A4621D6B059E CRC64;
     MESRDLNLRE RQVLGIIIQA YVVSAAPVGS RYIARNCNLG LSDATIRNVM ADLEDEGYIS
     QPHTSAGRTP TDKGYRYYVD LIMKVRRVND EEKKRIDADF GQLTTERRGS SSEVLLSAAK
     VLGSISRQLS VVLSPALSNA VFEKLDMVLL SSTRMMVILS IQSLIVKTIV MELDLAVSRQ
     EVSGVVDLLN QRLSGLTLSE IRKTISMRLS DCLADASLIN FVVRSAGQLF DETPIIERLY
     ISGAGYIVDQ PEFKQPEKVR DFITMIEDKF SVAKLVERNR IYSETVHPSR MEVSISIGKE
     NRERKAEDLT IVSTPYYVGG MMGKLGILGP TRMDYGHAVS VLNYMADCLS ATLSEVN