ID   HRCA_CHLPN              Reviewed;         398 AA.
AC   Q9Z850; Q9JQI8; Q9K2B2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=CPn_0501, CP_0253, CpB0521;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF38116.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP98450.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE001363; AAD18641.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38116.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000008; BAA98707.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98450.1; ALT_INIT; Genomic_DNA.
DR   PIR; A86553; A86553.
DR   PIR; B81598; B81598.
DR   PIR; G72070; G72070.
DR   RefSeq; NP_224697.1; NC_000922.1.
DR   RefSeq; WP_010883139.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z850; -.
DR   SMR; Q9Z850; -.
DR   STRING; 115711.CP_0253; -.
DR   PRIDE; Q9Z850; -.
DR   EnsemblBacteria; AAD18641; AAD18641; CPn_0501.
DR   EnsemblBacteria; AAF38116; AAF38116; CP_0253.
DR   GeneID; 45050544; -.
DR   KEGG; cpa:CP_0253; -.
DR   KEGG; cpj:hrcA; -.
DR   KEGG; cpn:CPn_0501; -.
DR   KEGG; cpt:CpB0521; -.
DR   PATRIC; fig|115713.3.peg.560; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..398
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182467"
SQ   SEQUENCE   398 AA;  45156 MW;  2541129FF9111B57 CRC64;
     MLSVTIVLVG LEMARSKVSK RDSKILDILF ATTELYLKTG QPVGSKTLKE SFCSDLSTAT
     IRNYFAELEA EGFLKKNHTS GGRIPTDLAL RHYVDHQEEC PEAEISAPIF DKISQLPSES
     RNIIKDLQKA TELLGEILDL PTFFSSPRFE NDSVTNIQIT QVDKQRAVTI LSTEFGQIFT
     DTLWLPEACD TLSIKRIEKF LQNYIRKLPT NEELSKKEEH LSMSLYNEVV VRYLTRYCNF
     SEEDLYQTGM SKLLKYEAFK DPEVLALGLS LFENRRQMCE LLNIGMHKGR ATAFIGKELS
     DILGTSNPGC SVITIPYYMN RSPLGALGIL GPINLPYKEA LPLLKLFANK INETLTQSFY
     KFKLSFRRPL TSNCKLSNEP ILRTEYSSIK LLPSKETL