ID   HRCA_CHLTA              Reviewed;         392 AA.
AC   Q3KLV9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CTA_0429;
OS   Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=315277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-571B / DSM 19440 / HAR-13;
RX   PubMed=16177312; DOI=10.1128/iai.73.10.6407-6418.2005;
RA   Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT   "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT   genitotropic strains.";
RL   Infect. Immun. 73:6407-6418(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000051; AAX50663.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3KLV9; -.
DR   SMR; Q3KLV9; -.
DR   EnsemblBacteria; AAX50663; AAX50663; CTA_0429.
DR   KEGG; cta:CTA_0429; -.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002532; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010396"
SQ   SEQUENCE   392 AA;  44928 MW;  123BE73D381DAC7F CRC64;
     MENRIEMSQL RASKKDSKIS YVLLMATKLY LESSQPVGSK LLKETYCSDL SSATIRNYFA
     QLETDGFLRK NHISGGRIPT DLAFRYYVDH NVPFLEQEEI LAIQQKLTEL PEYSKNIVKD
     LQKASEVLSD ILQLPVCFSS PRFESDSVIN IQLVAIDDQR VVFVLSTEFG QVFTDVLWLP
     EQLPENSLKR IEGFLQNYLR KQPSDGLLSQ KEEDLGMVLY NEVVVRYLTR YCHFSEEDLY
     QTGLSRLLKY GTFKEPETLA QGLAFFENRK HMCQLLNTYL HKETPTAFIG RELADIVGNT
     DPSCAVITIP YYMDHTPLGA FGVLGPMNLP YQQVFGTLSL FTERLKVILT QSFYKFKLSF
     RRPCPTDPRC SQRPAELTRS SSIKLLPAKE LS