ID   HRCA_CHLTB              Reviewed;         392 AA.
AC   B0BC29;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CTLon_0647;
OS   Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471473;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCH-1/proctitis;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AM884177; CAP07044.1; -; Genomic_DNA.
DR   RefSeq; WP_012263647.1; NC_010280.2.
DR   AlphaFoldDB; B0BC29; -.
DR   SMR; B0BC29; -.
DR   KEGG; ctl:CTLon_0647; -.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000794; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092805"
SQ   SEQUENCE   392 AA;  44979 MW;  91DFD736767DC5ED CRC64;
     MENRIEMSQL RASKKDSKIS YVLLMATKLY LESGQPVGSK LLEETYCSDL SSATIRNYFA
     QLETNGFLRK NHISGGRIPT DLAFRYYADH NAPFLEQEEI LAIQQKLTEL PEYSKNIVKD
     LQKASEVLSD ILQLPVCFSS PRFESDSVIN IQLVAIDDQR VVFVLSTEFG QVFTDVLWLP
     EQLPENSLKR IEGFLQNYLR KQPSDSLLSQ KEEDLGMVLY NEVVVRYLTR YCHFSEEDLY
     QTGLSRLLKY ETFKDPETLA QGLAFFENRK HMCQLLNTYL HKETPTAFIG RELTDIVGNT
     DPSCAVITIP YYMDRTPLGA FGVLGPMNLP YQQVFGTLSL FTERLKVILT QSFYKFKLSF
     RRPCPTDPRC SQRPAELTRS SSIKLLPAKE LS