ID   HRCA_CHLTR              Reviewed;         392 AA.
AC   P36426; O84399;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CT_394;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E/UW-5/Cx;
RX   PubMed=8045424; DOI=10.1016/0378-1119(94)90322-0;
RA   Schmiel D.H., Wyrick P.B.;
RT   "Another putative heat-shock gene and aminoacyl-tRNA synthetase gene are
RT   located upstream from the grpE-like and dnaK-like genes in Chlamydia
RT   trachomatis.";
RL   Gene 145:57-63(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25105; AAA23162.1; -; Genomic_DNA.
DR   EMBL; AE001273; AAC67991.1; -; Genomic_DNA.
DR   PIR; H71520; H71520.
DR   RefSeq; NP_219904.1; NC_000117.1.
DR   RefSeq; WP_010725181.1; NC_000117.1.
DR   AlphaFoldDB; P36426; -.
DR   SMR; P36426; -.
DR   STRING; 813.O172_02145; -.
DR   EnsemblBacteria; AAC67991; AAC67991; CT_394.
DR   GeneID; 884723; -.
DR   KEGG; ctr:CT_394; -.
DR   PATRIC; fig|272561.5.peg.424; -.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   InParanoid; P36426; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182469"
FT   VARIANT         33
FT                   /note="G -> S (in strain: E/UW-5/Cx)"
FT   VARIANT         213
FT                   /note="K -> E (in strain: E/UW-5/Cx)"
FT   VARIANT         320
FT                   /note="A -> T (in strain: E/UW-5/Cx)"
SQ   SEQUENCE   392 AA;  44948 MW;  FA2B74FEC90F9A18 CRC64;
     MENRIEMSQL RASKKDSKIS YVLLMATKLY LEGGQPVGSK LLKETYCSDL SSATIRNYFA
     QLETDGFLRK NHISGGRIPT DLAFRYYADH NAPFLEQEEI LAIQQKLTEL PEYSKNIVKD
     LQKASEVLSD ILQLPVCFSS PRFESDSVIN IQLVAIDDQR VVFVLSTEFG QVFTDVLWLP
     EQLPENSLKR IEGFLQNYLR KQPSDSLLSQ KEKDLGMVLY NEVVVRYLTR YCHFSEEDLY
     QTGLSRLLKY ETFKDPETLA QGLAFFENRK HMCQLLNTYL HKETPTAFIG RELTDIVGNT
     DPSCAVITIP YYMDRTPLGA FGVLGPMNLP YQQVFGTLSL FTERLKVILT QSFYKFKLSF
     RRPCPTDPRC SQRPAELTRS SSIKLLPAKE LS