ID   HRCA_CLOAB              Reviewed;         343 AA.
AC   P30727;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CA_C1280;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 4259 / DSM 1731 / NCIB 619;
RX   PubMed=1577695; DOI=10.1128/jb.174.10.3290-3299.1992;
RA   Narberhaus F., Giebeler K., Bahl H.;
RT   "Molecular characterization of the dnaK gene region of Clostridium
RT   acetobutylicum, including grpE, dnaJ, and a new heat shock gene.";
RL   J. Bacteriol. 174:3290-3299(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- INDUCTION: By heat shock.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; M74569; AAA23244.1; -; Genomic_DNA.
DR   EMBL; AE001437; AAK79251.1; -; Genomic_DNA.
DR   PIR; D41873; D41873.
DR   PIR; H97057; H97057.
DR   RefSeq; NP_347911.1; NC_003030.1.
DR   RefSeq; WP_010964592.1; NC_003030.1.
DR   AlphaFoldDB; P30727; -.
DR   SMR; P30727; -.
DR   STRING; 272562.CA_C1280; -.
DR   DNASU; 1117463; -.
DR   EnsemblBacteria; AAK79251; AAK79251; CA_C1280.
DR   GeneID; 44997786; -.
DR   KEGG; cac:CA_C1280; -.
DR   PATRIC; fig|272562.8.peg.1481; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182471"
SQ   SEQUENCE   343 AA;  38876 MW;  5436C696D2ABBE93 CRC64;
     MEMEERKLKI LQAIINDYIN NGEPVGSRTI AKKYNLGISS ATIRNEMADL EEMGYIEQLH
     TSSGRKPSDK GYRLYVDRLM EIPSMSVEEE MLIKAKIIDS ALYEIDKLVK QAMSLVSEMT
     KLTCVVKSLS ARKSYIKSIS LINIEPNMIL CVFITDSGMI KNSIIRVKSN IENSSLERIA
     NILNSKLKGL TIEQINLEVI NNIKKDLREY GHIFDCIMPN LYDILREADS TEVYKEGTMN
     IFNYPEFKDI EKAKEFLSVI DDRRILDTLF NASGGVTVNI GNENSIKEAR DFSVVSSVYK
     YNGRPLGTIG IIGPTRIPYS KVIKVIMEVV DQINNNLDKM NNS