ID   HRCA_CLOD6              Reviewed;         339 AA.
AC   Q182F0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CD630_24630;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AM180355; CAJ69350.1; -; Genomic_DNA.
DR   RefSeq; WP_004454754.1; NZ_CP010905.2.
DR   RefSeq; YP_001088977.1; NC_009089.1.
DR   AlphaFoldDB; Q182F0; -.
DR   SMR; Q182F0; -.
DR   STRING; 272563.CD630_24630; -.
DR   DNASU; 4916453; -.
DR   EnsemblBacteria; CAJ69350; CAJ69350; CD630_24630.
DR   GeneID; 66354861; -.
DR   KEGG; cdf:CD630_24630; -.
DR   KEGG; pdc:CDIF630_02709; -.
DR   PATRIC; fig|272563.120.peg.2602; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q182F0; -.
DR   BioCyc; PDIF272563:G12WB-2618-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010398"
SQ   SEQUENCE   339 AA;  38215 MW;  DC568CBE5A77462E CRC64;
     MELNERKLNI LKAIVKDYIE TAEAIGSRTI SKRHDLGVSA ATIRNEMADL EELGYLIQPH
     TSAGRVPSEK GYKLYVNSLM SKSELDDNDK ILIEQCMNHN INHIKELIHE TSKLLSQLTN
     YTTVAVTKSL INQSVIKHIQ LVAMNDNNIL LIVVTDKGDL KKANLTTNVY LDQSKLNLIS
     DNLTRKLLGK SITDLDDNLI AFIKYEISEY SGLIDELLNA LNSNMKEEDF SLSLNGATNI
     FSYPEFNDVL KAKSFLNMLE KKETIADIIK SKGIQKDNLN IIIGSDNDCE LAQDCSIVTA
     TYNVDRDLVG RISFIGPTRM DYARIYSIIN YMSLLINRK