ID   HRCA_CLOPE              Reviewed;         339 AA.
AC   Q8XIS9;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CPE2035;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000016; BAB81741.1; -; Genomic_DNA.
DR   RefSeq; WP_003454856.1; NC_003366.1.
DR   AlphaFoldDB; Q8XIS9; -.
DR   SMR; Q8XIS9; -.
DR   STRING; 195102.gene:10491305; -.
DR   EnsemblBacteria; BAB81741; BAB81741; BAB81741.
DR   KEGG; cpe:CPE2035; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182472"
SQ   SEQUENCE   339 AA;  37980 MW;  E72F49086ACAF7C3 CRC64;
     MIDDRKLQIL RAIIQDYIST GEPVGSRTIA KKYNLGVSSA TIRNEMADLE DMGFLEQPHT
     SAGRIPSSRG YRLYVDRMIE FERLSSEEEG LIRNSIIDGT LYEVDKIIKQ TSALLSELTK
     MTCIVKAPSV HKSFVKSIQL LKVDDVSILC VLVTDNGVIR NTVIKVKSVP ISEELIKISK
     IITERLKNLT IEQINLEVIS NLNRALSGYE DIVNAVLPAL YESLKGDETS EVFLEGTINI
     FNYPEYNNIH KAKEILELLH DKKSISELIS DSDDMTVKIG DEIFVPEAKE CSIISAGYHV
     GDKSLGTIAL IGPRRINYSK VLSIMTEVMK ELNETLKNK