ID   HRCA_CLOTE              Reviewed;         351 AA.
AC   Q892Q8;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CTC_02033;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE015927; AAO36536.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q892Q8; -.
DR   SMR; Q892Q8; -.
DR   STRING; 212717.CTC_02033; -.
DR   EnsemblBacteria; AAO36536; AAO36536; CTC_02033.
DR   KEGG; ctc:CTC_02033; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182473"
SQ   SEQUENCE   351 AA;  39772 MW;  FB99668CDE42489F CRC64;
     MLINGVIIME MDKRKIKILQ AIIHDYIQTA EPVGSRTIAK KYDLGVSSAT IRNEMSDLED
     MGYLEQLHSS SGRKPSDKGY RLYVDKLMNI QKLSSMEECA IKTHIINSAL YEIEKVVREA
     SAILADLTKL TTVVMSPSSI ESYIKSIQLI GLDANTVLLV LVIDTGIIKN NVIKLHAKMT
     IDELVKINRI LNIKLNKIRV ESINLDFLKV VLEEFKDYEK WLKDILPVLY ETLLSGIDSN
     EIYLEGATNI FNYPEYNDIQ RAKDFLSLID DKDKVKNLIK SDDNITIKIG KENFIEDAKD
     CTIITAVYKL KDRPLGTIGV IGPTRMPYSR VVSILSTLVD ELDKLLKDDN I